Drop in a sequence (FASTA, GenBank, or just paste it in) and see every base at native resolution. No tiling, no downsampling. The transcript becomes something you can actually hold and trust.
02 Annotate
Features and modified bases, layered in context.
Mark features, regions, and modified positions on one shared coordinate space. Click any base and see its context at once: its feature, its place inside a hairpin.
03 Fold
Secondary structure, straight from the engine.
Thermodynamic folding: minimum free energy and partition function. Hairpins draw themselves, and base-pair probabilities and ΔG come from an engine that holds its own against the field's standard tools.
04 Design
From sequence to oligo, without leaving the page.
Select a region, design primers and antisense oligos, and check Tm and structure on the same engine that folds. The transcript becomes a document you can author against.
The desktop app
One surface. Many tracks. On your machine.
nuvekta runs natively on macOS and Windows today, with Linux to follow. Your sequences, structures, and annotations live on one surface, and it works offline. Built in React, TypeScript, and Tauri, with a custom canvas-and-SVG renderer.
nuvekta · synNGS-mRNA-Δ04
Views
Sequence
Structure
Plasmid
Enzymes
Features
Alignment
Primers
ASO Design
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A stylized illustration of the workspace, not a screenshot. A real capture lands here as the app firms up.
Platform
Everything a sequence wants to be.
What works today, and what we're building next. We tag each one honestly, and never call something shipped before it is.
Sequence Viewer Live
Base-accurate rendering. Drag to select, click to annotate, jump anywhere. Multiple tracks sharing one coordinate space.
Structure Viewer Live
Secondary structure in 2D, with planar, circular, and linear layouts. Fold it, melt it by temperature, inspect any base. ΔG and base pairs come from the engine.
Compare Live
Fold two variants, or one sequence at two temperatures, side by side in linked panels. Mutations are marked in place, so a change in structure is attributable to a change in sequence.
Modified-Base Folding Live
Fold RNA with modified nucleotides like m1Ψ, pseudouridine, and inosine, the chemistry behind mRNA therapeutics and ADAR editing. Modifications are checked against the base they sit on before they can change a number.
Melting & Temperature Live
Melting temperatures and melt curves from the partition function, so you can see how a structure opens as the temperature climbs.
Inverse Folding Live
Draw the structure you want and search for sequences that fold into it, scored on the same thermodynamic engine that verifies the result.
Primer & Oligo Design Live
Design primers over any region with Tm, GC, hairpin, and dimer QC, then check the oligo's own structure on the engine that folds the target.
ASO & Duplex Design Live
Walk antisense oligos across a transcript, rank candidates on accessibility and duplex thermodynamics, and inspect the hybrid base by base.
Plasmid, Enzymes & Cloning Live
Circular maps with features in place, restriction digests with cut sites on the same coordinates, and fragment assembly planned against them.
Sequence Alignment Live
Align two sequences and compare them base by base, global (Needleman–Wunsch) or local (Smith–Waterman), with an identity score and a dot-plot view.
Construct Workbench In development
Assemble an mRNA construct from its parts — 5′ UTR, CDS, 3′ UTR, tail — and fold the whole thing, not just the piece you edited.
AI Model Development Planned
Learned models for RNA design and structure. An active research direction for us, trained and checked against the thermodynamic engine rather than replacing it.
Early access
Want in early?
We're onboarding a small group of early users: RNA labs, oligo and mRNA teams, and anyone who lives in sequence files. Leave your email and we'll reach out as the platform opens up.